Does TMAO cause Heart Disease? | Kevin Klatt PhD RD

Опубликовано: 26 Март 2025
на канале: Nutrition Made Simple!

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Is TMAO a cause of heart disease or an innocent bystander? What is TMAO and what foods raise it? Should we avoid foods high in TMAO (or foods that raise TMAO levels)?

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References:
TMAO production from choline & carnitine:
https://www.mdpi.com/2072-6643/12/5/1330

TMAO & risk of disease:
https://link.springer.com/article/10....
https://www.ncbi.nlm.nih.gov/pmc/arti...

TMAO genetics (mendelian randomization):
https://www.sciencedirect.com/science...
https://www.mdpi.com/1422-0067/24/3/1940

What fraction of TMAO level is explained by diet?
https://onlinelibrary.wiley.com/doi/a...

TMAO & microbiome:
https://www.nature.com/articles/nm.3145.

TMAO, whole grains and fish:
https://www.sciencedirect.com/science...

Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.

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0:00 What is TMAO?
1:35 Cause or innocent bystander?
3:22 Randomized trials
4:16 Genetics
5:37 TMAO levels
7:14 Observational studies
10:37 Diet vs endogenous production
12:04 Whole grains and fish
15:42 Individual nutrients
19:25 Small effects