Benjamin Franklin Biostasis Conjecture Symposium - Lance B. Becker
At the April 2024 meeting of the American Philosophical Society, Lance Becker, Chair, Emergency Medicine, Northwell Health, introduced and framed the inaugural Benjamin Franklin Biostasis Conjecture Symposium.
About the speaker:
Lance Becker, MD, joined Northwell Health in 2015 as chair of the Department of Emergency Medicine at North Shore University Hospital and Long Island Jewish Medical Center, Dorothy and Jack Kupferberg Professor and chair of emergency medicine at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, and an investigator at the Feinstein Institutes for Medical Research.
A national and international leader in academic emergency medicine, critical care and resuscitation science, Dr. Becker has research interests that are translational and extend across the basic science laboratory into animal models of resuscitation and to human therapies. He has been a leader in the field of resuscitation for more than 25 years, pioneering advances in improving the quality of CPR, AED use, defining the “three-phase” model for cardiac arrest care and therapeutic hypothermia. He has worked closely with the American Heart Association in emphasizing the importance of a “systems of care” approach to improving survival within communities.
Dr. Becker’s cellular studies have helped define reperfusion injury mechanisms, mitochondrial oxidant generation, reactive oxygen and nitrogen species responses to ischemia, apoptotic activation following ischemia, signaling pathways, new cellular cytoprotective strategies and hypothermia protection. He has received numerous honors and awards from organizations such as the American Heart Association, the American College of Emergency Physicians and American Society of Critical Care.
A recipient of prestigious teaching awards, Dr. Becker has mentored many successful researchers. He is a renowned, well-funded researcher who holds many patents for his discoveries. His professional affiliations include membership in the American Heart Association, Society of Academic Emergency Medicine, the US Institute of Medicine, the National Academy of Science, the American College of Emergency Physicians and the American Physiological Society. In addition, he holds many offices in professional and scientific societies, and has organized many national and international scientific meetings. He is an elected member of the Institute of Medicine/National Academy of Medicine.
Before joining Northwell, Dr. Becker was founder and director of the Center for Resuscitation Science at the Hospital of the University of Pennsylvania in Philadelphia, and professor of the Center for Mitochondrial and Epigenomic Medicine at the Children’s Hospital of Philadelphia. He was previously founder and director of the Emergency Resuscitation Center at the University of Chicago and Argonne National Laboratory.
Dr. Becker received his medical degree from the University of Illinois, College of Medicine.
Chapters:
00:00 - Introduction and Welcome
00:41 - Overview of Biostasis Symposium Goals
01:07 - Defining Biostasis and Its Tools
01:26 - Heart-Lung Machines and Temperature Control
01:51 - Drugs for Cell Protection in Biostasis
02:18 - Life, Death, and Biostasis Opportunities
02:58 - Medical Applications of Biostasis
03:29 - Exploring Oxygen and Mitochondrial Injury
04:27 - Ethics and Access in Biostasis Research
05:20 - Biostasis: Hibernation and Suspended Animation
06:21 - Nature’s Lessons in Biostasis
07:08 - Life, Death, and Resuscitation in the ER
08:33 - Time Sensitivity in Medical Biostasis
10:01 - Reoxygenation and Mitochondrial Death Switch
13:09 - Advances in Mitochondrial Research
15:42 - New Perspectives on Cellular Life and Death
17:00 - Mitochondrial Transplantation Insights
19:19 - Developing Multi-Drug Cocktails for Resuscitation
21:06 - Mitochondrial Transplants and Survival Rates
About American Philosophical Society:
The American Philosophical Society, the oldest learned society in the United States, was founded in 1743 by Benjamin Franklin for the purpose of “promoting useful knowledge.” In the 21st century we sustain this mission in three principal ways. We honor and engage leading scholars, scientists, and professionals through elected membership and opportunities for interdisciplinary, intellectual fellowship, particularly in our semi-annual Meetings. We support research and discovery through grants and fellowships, lectures, publications, prizes, exhibitions, and public education. We serve scholars through a research library of manuscripts and other collections internationally recognized for their enduring historic value. The American Philosophical Society’s current activities reflect the founder’s spirit of inquiry, provide a forum for the free exchange of ideas, and convey our conviction that intellectual inquiry and critical thought are inherently in the best interest of the public.
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