The Science of Metabolic Health: Mitochondria, Zone 2, Diet, Fat Storage | The Proof Podcast EP

Опубликовано: 05 Июнь 2025
на канале: The Proof with Simon Hill

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Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists in Episode #329. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease.

👇 Visit The Proof website for the full show notes and supporting studies. 👇 https://theproof.com/podcast/

In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD.

Specifically, we discuss:
00:00 - Intro
01:35 - What is Metabolic Health
07:02 - Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility
20:03 - The Importance of Skeletal Muscle for Metabolic Health
28:36 - Exercise for Metabolic Health - Zone 2
56:45 - Twin Cycle Hypothesis
01:08:15 - Understanding the Personal Fat Threshold
01:17:08 - Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor
01:36:46 - Are DASH, Nordic, Mediterranean, and Portfolio Diets Good for Preventing and Managing Diabetes?
01:42:39 - Understanding Non-Alcoholic Fatty Liver Disease and Its Development
01:49:37 - The Science of Hepatic Fat Oxidation
01:55:14 - Consequences and Effects of Fatty Liver Disease
02:00:42 - Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes
02:13:21 - Combination of Fructose and Saturated Fat on Metabolic Health
02:17:35 - Type of Fat and Its Effect on Metabolic Health
02:24:01 - What Causes Metabolic Health: Fat or Fructose
02:27:50 - New Fat Storage Mechanisms - Personal Fat Threshold
02:31:52 - Modern Techniques for Accurate Body Fat Measurement
02:36:51 - Health Metabolic Biomarkers
02:38:19 - Ectopic Fat
02:39:10 - Fat Storage and Metabolic Health
02:42:02 - Evolutionary Insights into Human Fat Storage
02:45:46 - Fatty Liver Disease
02:57:46 - Outro

Connect with featured guests:
Inigo San Millan, PhD: https://theproof.com/tag/inigo-san-mi...
Don Layman, PhD: https://theproof.com/tag/don-layman/
Roy Taylor, PhD: https://theproof.com/tag/roy-taylor/
Andrea Glenn, PhD, RD: https://theproof.com/tag/andrea-glenn/
Alan Flanagan, PhD: https://theproof.com/tag/alan-flanagan/
Richard Johnson, MD: https://theproof.com/tag/richard-john...
Christos Mantzoros MD, DSc, PhD: https://theproof.com/tag/christos-man...

The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends.

Enjoy, friends.
Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com http://theproof.com/ and host of The Proof with Simon Hill https://theproof.com/podcast/

Author of The Proof is in the Plants https://theproof.com/book/

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