The Science of Fat Loss: Expert Strategies for Weight Reduction and Cardiometabolic Health The Proof

Опубликовано: 06 Июнь 2025
на канале: The Proof with Simon Hill

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Struggling to keep weight off long term? Join me in Episode #335 as I sit down with Kevin Maki, PhD and Carol Kirkpatrick, PhD to discuss the science behind successful fat loss and maintenance. We explore evidence-based strategies to lose body fat and keep it off, focusing on the roles of nutrition, exercise, and pharmacological interventions, with practical tips to help you achieve lasting results.

👇 Visit The Proof website for the full show notes and supporting studies. 👇 https://theproof.com/podcast/

Dr Kevin Maki is the Founder and Chief Scientist at Midwest Biomedical Research and an Adjunct Professor at Indiana University’s School of Public Health. A past president of the National Lipid Association, he’s an expert in human nutrition and chronic disease research. Dr Carol Kirkpatrick is a clinical scientist at Midwest Biomedical Clinical Research and adjunct faculty at Idaho State University. A registered dietitian nutritionist and clinical lipid specialist, she has authored numerous guidelines for managing cardiometabolic risk through nutrition. Together, they offer deep expertise on weight management and cardiovascular health.

Connect with Dr Kevin Maki:
LinkedIn: / kevin-c-maki-phd-497ba34
MB Clinical Research and Consulting: https://www.mbclinicalresearch.com/

Connect with Dr Carol Kirkpatrick:
Twitter/X: https://x.com/carolkirkpat3
LinkedIn: / carol-fellows-kirkpatrick-phd-rdn-cls-48a395a

If you have any additional questions you would like answered in the future, let me know in the comments.

The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends.

Enjoy, friends.
Simon

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00:00 - Introductions
05:33 - Carol’s Journey into Nutrition and Research Development
12:59 - Kevin’s Path in Cardiometabolic Health Research
16:05 - The Importance of Observational Studies in Nutrition
20:55 - Understanding Dietary Fats and Cardiometabolic Health
33:01 - Public Health Nutrition: Current Challenges and Opportunities
44:25 - Exploring Obesity and Its Impact on Metabolic Health
54:41 - How Exercise Enhances Insulin Sensitivity
56:07 - The Link Between Insulin Resistance and Ectopic Fat
01:02:11 - Weight Loss Challenges: Why It’s So Hard to Keep the Weight Off
01:05:08 - How GLP-1 Agonists Are Transforming Obesity Treatment
01:12:28 - Behavioural Aspects of Obesity: Understanding the Psychology
01:28:20 - The 30-30-30 Study: A New Approach to Sustainable Weight Loss
01:45:08 - Cholesterol, Fibre, and Cardiovascular Health
01:48:02 - Protein Supplements and How They Affect Digestion
01:50:29 - Dietary Patterns and Regulating Appetite for Better Health
01:52:55 - Exploring the 30-30-30 Framework for Weight Loss
01:58:59 - How Protein Sources Influence Metabolic Health
02:16:03 - Carbohydrate Quality vs. Restriction: What Matters More?
02:28:18 - Exercise for Weight Maintenance and Long-term Health
02:31:31 - The Future of Nutrition Research and Public Health
02:36:16 - Final Thoughts