The Chirality Paradox
L-DOPA is the best drug we have for Parkinson’s disease. If you take L-DOPA and reflect it in a mirror, you get a different molecule: D-DOPA, which does absolutely nothing for Parkinson’s and causes potentially deadly side effects. Making just L-DOPA without D-DOPA is surprisingly hard – so hard that the person who finally figured out how to do it won the 2001 Nobel Prize in Chemistry.
00:00 Intro
00:35 Chirality
02:25 Racemic drugs
02:44 Parkinson’s disease
03:56 Option 2
07:02 The 2001 Nobel
09:03 Turtles all the way down
#ParkinsonsDisease #Parkinsons #LDOPA #DDOPA #Chirality #Enantiomers #NobelPrizeChemistry #DrugSynthesis #PharmaceuticalChemistry #Pharma #ChemicalReactions #Chemistry #OriginsOfLife #TurtlesAllTheWayDown
Credits:
Executive Producer:
Matthew Radcliff
Producers:
Andrew Sobey
Elaine Seward
Darren Weaver
Writers:
George Zaidan
Hosts:
George Zaidan
Scientific Consultants:
Eric Jacobsen Ph.D.
Brianne Raccor, Ph.D.
Michelle Boucher, Ph.D.
Executive in Charge for PBS: Maribel Lopez
Director of Programming for PBS: Gabrielle Ewing
Assistant Director of Programming for PBS: John Campbell
Reactions is a production of the American Chemical Society.
© 2024 American Chemical Society. All rights reserved.
Sources:
https://docs.google.com/document/d/1_...
