Data volumes and security requirements present serious challenges for real-time analysis. Sqrrl Enterprise and Apache Accumulo enable online model building and dynamic indexing to support both retrospective analysis and enrichment of streaming data. These mechanisms are built on a foundation of fine-grained access control, supporting a bloom of innovative applications without sacrificing security. This talk will outline the framework that we use to support secure, scalable real-time analysis, as well as dive deeper into many of the supporting features.