Brain-Derived Neurotrophic Factor with Release in the Central Nervous System
A self-assembled nanoformulation delivers active brain-derived neurotrophic factor (BDNF) to the central nervous system via the intranasal-to-brain pathway. The polyion complex formed by electrostatic interactions between BDNF and poly(ethylene glycol)-b-poly(l-glutamic acid) stabilizes the protein and delivers it to the brain at significantly higher rates than the native protein, and releases BDNF exclusively to its receptors upon contact. This is reported by Yuhang Jiang, James M. Fay, Chi-Duen Poon, Natasha Vinod, Yuling Zhao, Kristin Bullock, Si Qin, Devika S Manickam, Xiang Yi, William A. Banks, and Alexander V. Kabanov in the article https://doi.org/10.1002/adfm.201703982. To know more, please go to the Advanced Functional Materials homepage.
