In this python tutorial, we will go over how to create widgets with Tkinter. This tutorial will focus on introducing some common widgets. Note, for large programs / complex applications consider using an object oriented (classes) approach.
The tkinter package ("Tk interface") is the standard Python interface to the Tk GUI toolkit. Both Tk and tkinter are available on most Unix platforms, as well as on Windows systems. Source: python documentation
You can use Tkinter to create GUI applications.